Maximising follow-up participation rates in a large scale 45 and Up Study in Australia
© Bauman et al. 2016
Received: 1 September 2015
Accepted: 23 March 2016
Published: 14 April 2016
The issue of poor response rates to population surveys has existed for some decades, but few studies have explored methods to improve the response rate in follow-up population cohort studies.
A sample of 100,000 adults from the 45 and Up Study, a large population cohort in Australia, were followed up 3.5 years after the baseline cohort was assembled. A pilot mail-out of 5000 surveys produced a response rate of only 41.7 %. This study tested methods of enhancing response rate, with three groups of 1000 each allocated to (1) receiving an advance notice postcard followed by a questionnaire, (2) receiving a questionnaire and then follow-up reminder letter, and (3) both these strategies.
The enhanced strategies all produced an improved response rate compared to the pilot, with a resulting mean response rate of 53.7 %. Highest response was found when both the postcard and questionnaire reminder were used (56.4 %) but this was only significantly higher when compared to postcard alone (50.5 %) but not reminder alone (54.1 %). The combined approach was used for recruitment among the remaining 92,000 participants, with a resultant further increased response rate of 61.6 %.
Survey prompting with a postcard and a reminder follow-up questionnaire, applied separately or combined can enhance follow-up rates in large scale survey-based epidemiological studies.
KeywordsEpidemiological studies Follow-up Response rates Recruitment strategies
The majority of population-based cohort studies rely on individuals’ willingness to give their time and effort to participate. In recent decades, many epidemiological cohort studies have experienced declining participation or response rates, raising concerns about the usefulness of cohort findings for research and practice [1, 2] and posing practical and methodological challenges. Chief among these is identifying strategies to maximising response rates for assuring external validity of the findings. Maximising participation rates at recruitment and during the follow-up period is crucial, given that the characteristics of non-responders may show a socio-economic gradient  or higher mortality than survey responders .
For many decades, researchers have attempted to increase response rates to postal questionnaires. An early systematic review  and a meta-analysis  identified factors such as increased contacts and reminders, pre-notification by mail, credible sources of the study and perceived relevance of the topic can influence study participation rates. A Cochrane review summarised strategies to increase postal questionnaire responses, and identified incentives, personalising follow up, and follow-up reminder questionnaires as among strategies that effectively increased response rates . Despite the plethora of research, most studies were small-to-mid sized (less than 1000 people approached) [e.g. 9], and most assessed recruitment to enrol in a study or trial [8, 9]. A more recent report described recruitment to an epidemiological cohort  and another identified that different population subgroups responded differently to multiple mail-out reminders .
Retention is a further concern within cohort studies, with loss to follow-up as a recognised problem that may cause greater bias than initial recruitment. In recent years, researchers have focused effort on baseline recruitment, but few studies have tested different recruitment strategies to increase subsequent retention for follow-up in large population-based cohorts. Strategies to increase retention have been trialled in HIV prevention studies in younger adults  and in one cardiac trial, home visiting increased study retention . Reminder letters, together with the provision of stamped or business-reply envelopes and delivery of a newsletter have also influenced follow-up response rates . An older adult trial for neck injuries trialled a £5 incentive to increase four- and eight-month questionnaire returns, and achieved higher responses, but at a cost of £67 per additional questionnaire received . A recent systematic review found incentives increased retention rates (increasing with higher values) in population-based cohort studies . Overall, the research to date has used similar strategies for increasing recruitment and achieving continuing participation during the follow-up period. Existing evidence withstanding, little research has addressed retention in epidemiological cohort studies, using different postal pre-notification (advance notice) and reminder approaches to maximise follow-up questionnaire responses sent several years after the baseline. Additionally, it is important to consider that the factors influencing participation and retention may be different; that is, it is possible that different mechanisms may operate once a participant has consented and expect to be in a cohort study over an extended period.
This study focuses on a 3.5-year follow up of a large sub-sample of the 45 and Up Study Cohort . The follow up sub-study assesses social, environmental and economic factors (SEEF) and subsequent health outcomes, as well as changes in several baseline attributes from the 45 and Up Study. The recruitment goal of the SEEF Study was to re-contact the first 100,000 participants from the baseline 45 and Up Study and invite them to take part in the follow-up sub study (i.e. the SEEF Study). Recruitment for the SEEF Study was challenging, as it involved a large sample, and therefore low-cost methods for optimal follow-up strategies were required. This paper evaluates the strategies used to maximise the response rate to the SEEF Study and presents cost analysis of the strategies, to inform subsequent 45 and Up Study follow-up studies and large cohort studies elsewhere.
The 45 and Up Study assembled a large (n = 267,153) sample of adults aged 45 up to 110 years living in the state of New South Wales, Australia, with the objective of following their health status. Baseline data were collected between 2006 and 2009, and covered previous and current health status, behavioural risk factors and health service utilisation . Information on study design, sampling method and baseline cohort profile is reported elsewhere . Although the 45 and Up Study baseline response rate was modest (18%), representativeness is not essential in cohort studies and observed cross sectional exposure-outcome relationships were similar to state-based surveillance systems that reported much higher response rates [19–21].
Study design and data collection
an advance notice postcard followed by the SEEF questionnaire 2 weeks later (Strategy A);
a SEEF questionnaire followed by a reminder letter 2 weeks later (Strategy B), or;
an advance notice postcard, followed 2 weeks later by the SEEF questionnaire, followed another 2 weeks later by a reminder letter (Strategy C).
A statistician blinded to participant identity performed the randomisation sequence and was not involved in preparing the SEEF Study questionnaire packages for outward mailing; a logistics agency was contracted to administer the mail-put of questionnaire packages and staff were not informed of the allocation.
The 8-page questionnaire included a subset of repeated questions from the baseline 45 and Up survey (http://www.45andup.org.au) and additional questions on a range of social, psychological, economic and environmental factors associated with health and wellbeing. Questionnaire completion time varied from 30 to 45 min. Both the one-page reminder letter and the postcard provided brief information about the SEEF Study, an invitation to participate and were signed by the 45 and Up Study Scientific Director. Participants were provided with reply-paid envelopes to return their completed questionnaires.
In the final Phase 3, a combined strategy was used to recruit among the remaining 92,000 between late 2010 and early 2011; a questionnaire was mailed out, followed at 3 weeks by a reminder letter to non-responders. After a further 3 weeks, a second reminder with a questionnaire was mailed out to non-responders; this latter component was an adaptation of the Phase 2 study.
The study received ethical approval from the University of Sydney Human Research Ethics Committee (Ref No. 10-2009/12187); and the University of New South Wales Human Research Ethics Committee granted ethics approval for the 45 and Up Study (Ref No. HREC 05035).
The main outcome was participation in the SEEF Study, consisting of receipt of a completed SEEF questionnaire and signed consent form. Response rates were calculated as: those participating in SEEF divided by (those eligible for SEEF, minus participants whose letters were returned to sender, and who were not further followed). Response rates were examined overall, and by sex and age group, with age categories as 45–64, and 65 years and older.
In order to test the impact of each method of enhancement, we used generalised linear models with a log link and binomial distribution  with survey participation as the outcome, and condition (postcard (Strategy A), reminder (Strategy B), and reminder plus postcard (Strategy C) as the independent variable with no enhancement (Study 1) as the reference category. Planned contrasts between the three enhancement conditions were performed. Results are reported as prevalence ratios (PR). All analyses were conducted using Stata 13.0  and 0.05 the threshold for statistical significance.
Completed SEEF hard-copy questionnaire forms were scanned with optical character recognition software and compiled into an indexed SAS dataset . Costs of each recruitment strategy were computed, by summing printing and postage costs for each strategy, and assessing the cost per questionnaire received.
Recruitment strategies for Study 1 mail-out pilot and Study 2 of three enhanced mail-out strategies
Study and intervention arm of study
Date mailed out
Cost per unit received ($AU)
Responses 30 days after questionnaire mail-out
Overall RR (%) and 95 % CI
Aged 45–64 years
Aged 65+ years
Study 1 pilot
Questionnaire (Q) sent 24 March 2010
Study 2 enhanced mail-out
1000 Postcard + Questionnaire
Postcard 30 June 2010 + Q 7 July 2010
1000 Questionnaire + Reminder
Q 7 July 2010 + Reminder 21 July 2010
1000 Postcard + Questionnaire + Reminder
Postcard 30 June 2010 + Q 7 July 2010 + Reminder 21 July 2010
Compared to the pilot mail-out to 5000 participants in Study 1, the effect of sending a postcard when there is no reminder was 1.21 times as effective (95 % CI 1.13–1.30). Using a postcard prompt also resulted in increased likelihood of survey response (PR = 1.30, 95 % CI 1.22–1.39), as did if both a postcard and a reminder were sent out (PR 1.35, 95 % CI 1.27–1.44) (data not shown). The contrast analyses showed that using a reminder or a postcard were comparable, and adding a postcard to a reminder did not significantly improve the response rate compared to only sending a reminder. However, the combination of postcard and reminder was significantly better than postcard alone (PR 1.12, 95 % CI 1.03–1.21).
The costs of the recruitment per person were highest for Study 1, and similar for each strategy in Study 2. The most expensive enhanced recruitment approach was both reminder and postcard, which cost around $0.65 more than a postcard alone, per person recruited.
For the main SEEF Study mail-out (Phase 3 of this study), of the remaining 92,000 SEEF-eligible participants, a response rate of 61.6 % (95 % CI 61.3–61.9 %) was obtained, significantly higher than either Study 1 or Study 2. The recruitment approach for the main survey was an adaption of the Study 2 strategies and used a combination of mail-out, followed at 3 weeks by a reminder letter to non-responders, followed by a second reminder plus a questionnaire to the remaining non-responders.
Efficient methods for recruiting and following up existing participants are essential in large-scale prospective studies if they are to remain invaluable in epidemiological research. In this paper, we report the effectiveness of three enhanced recruitment strategies to improve follow up response rates in a social epidemiological study. The results of this study show that more intensive strategies can improve follow-up response rate. Among the three strategies trialled, the pre-postcard, mailed questionnaire and reminder mailed letter at 2 week intervals had the highest response rate. However, having any kind of prompt alone or in combination appears to be better than having no prompt, consistent with other studies using a pre-notification (advance notice) or reminders . Another epidemiological study also found similar follow-up response rates using reminder strategies based on style of return envelope and delivery of a newsletter . The cost analysis did not define a clear benefit, but all additional costs were cheaper per unit survey than in other research .
Overall, the SEEF study across Study 1, Study 2, and the subsequent adaptation that involved also sending a reminder questionnaire at follow-up resulted in 60,404 in the complete data set, indicating just over a 60 % response rate. This response rate represents a reasonable return rate at an acceptable cost, without compromising the scientific integrity of the study. Further, these results are within the ranges obtained by large epidemiological cohort studies . However, age differentials were observed in this study, with lower response among those aged over 65 years. Such age-related declines in response rates during follow-up period are expected in older adult cohort studies as a result of attrition due to deaths and disability [2, 26].
Our study found some gender differences to response based on the strategies used. Women receiving a questionnaire plus a reminder were more likely than their counterparts receiving a postcard and a reminder, separately or in combination, to respond to the survey. For men, a combination of pre-notification and reminders generated a substantially higher response rate in this group compared to women, suggesting that male participants may respond better to frequent prompts and reminders. In other research, frequent reminder prompts to male participants also indicated a positive effect on retention rates ; although to our knowledge no study had specifically looked at gender differentials to repeat contacts. Further research will need to investigate the impact of frequency and recruitment methods to boost follow-up response rates among men, a group widely known to be less likely to take part in research studies.
A major strength of this study is its sample size, with 8000 population-based individuals approached in the two studies. The literature to date shows that studies of similar scope and size are rarely conducted (typically less than a total of 1000). The cost analysis is another strength, indicating that the additional costs associated with the most intensive strategy (Strategy C) is marginal when considering the higher response rate generated by the strategy. Our study focused on postal questionnaires and did not examine ethnic differential effects which may limit its generalisability to studies involving large non-English speaking participants. This study did not model other factors that could predict participation (e.g. age, gender, health profile, timing of joining the baseline 45 and Up Study). We did stratify the analysis by gender and age, and found response rate differentials across these factors. It is possible that the lower response among the oldest age group (65+ years) may have been the result of natural attrition due to the higher risk of morbidity or mortality among this older age group. Due to the sequential nature of the group allocation to the three recruitment strategies, it is also plausible that the time since last contact may affect the response rates. We acknowledge that our study is further limited by the lack of description of the sub-samples which were targeted by the different strategies, as the varying response rates may be related to the socio-demographic and health-related characteristics.
While this study shows that any kind of reminder alone or in combination is better than having no reminder (Study 1), we cannot state in absolute term which of the three enhanced recruitment strategies (Study 2) is better than another. Further, the pilot recruitment phase occurred during Easter and therefore some of the improvements noted in the following two phases may be attributed to recruiting outside a major public holiday period.
This study explored alternate methods for increasing follow-up response rates in a large epidemiological cohort study. The findings indicated that increasing the follow-up intensity resulted in improved response rates. Specifically, we found that the pre-postcard, mailed questionnaire and reminder mailed letter at 2 week intervals alone or in combination were more effective in eliciting a higher response rate than no prompts at all. This study has made an important contribution to maximising the follow-up response rate, and consequently the usefulness of the SEEF Study follow up among older Australian adults. Recruitment and retention, however, will remain a significant challenge for epidemiological cohort studies. Future research in this area needs to consider developing and testing low-cost, innovative recruitment and retention strategies, including investigating potential mechanisms that may influence participation and whether these would vary by gender.
Social, Environmental and Economic Factors
AB conceptualized the study, designed the analysis, interpreted the results and drafted the manuscript. PP co-ordinated the study and data acquisition, contributed to drafting, interpretation of data, and reviewed the manuscript. AC co-ordinated sampling, recruitment of study participants, data management and cleaning, and reviewed the manuscript. EB contributed to concept and design of the study, interpretation of data, and involved in drafting and reviewing the manuscript. LJ conceived the study design, and reviewed the manuscript. KR performed sampling for the study, interpretation of data, and reviewed the manuscript. BJ conceived the study design, and reviewed the manuscript. AG carried out the analysis, interpretation of data and helped to draft the manuscript. All authors read and approved the final manuscript.
The authors thank the Sax Institute for permission to access the 45 and Up Study baseline participants for this study. The 45 and Up Study is managed by the Sax Institute in collaboration with major partner Cancer Council New South Wales; and partners the Heart Foundation (NSW Division); NSW Ministry of Health; beyondblue: the national depression initiative; Ageing, Disability and Home Care, NSW Family and Community Services; the Australian Red Cross Blood Service; and UnitingCare Ageing. We thank the thousands of Australian men and women for their ongoing participation and generous contributions to the 45 and Up Study and the SEEF Project. This study was funded by the National Health and Medical Research Council Strategic Award for Preventive Healthcare and Strengthening Australia’s Social Economic Fabric (The SEEF Project; ID402810). EB is supported by the NHMRC.
SEEF Project Investigators Sally Redman, Mark Harris, Julie Byles, Judith Clark, Don Nutbeam, Bryan Rodgers.
The authors declared no competing interest and received no financial support with respect to the research, authorship, and/or publication of this article.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
- Galea S, Tracy M. Participation rates in epidemiologic studies. Ann Epidemiol. 2007;17(9):643–53.View ArticlePubMedGoogle Scholar
- Steptoe A, Breeze E, Banks J, Nazroo J. Cohort profile: the English Longitudinal Study of Ageing. Int J Epidemiol. 2012;. doi:10.1093/ije/dys168.PubMedPubMed CentralGoogle Scholar
- Howe LD, Tilling K, Galobardes B, Lawlor DA. Loss to follow-up in cohort studies bias in estimates of socioeconomic inequalities. Epidemiology. 2013;24:1–9.View ArticlePubMedGoogle Scholar
- Jousilahti P, Salomaa V, Kuulasmaa K, Niemela M, Vartiainen E. Total and cause specific mortality among participants and non-participants of population based health surveys: a comprehensive follow up of 54,372 Finnish men and women. J Epidemiol Commun. 2005;59:310–5.View ArticleGoogle Scholar
- Kanuk L, Berenson C. Mail surveys and response rates: a literature review. J Market Res. 1975;12:440–53.View ArticleGoogle Scholar
- Fox RL, Crask MR, Kim J. Mail survey response rates: a meta analysis of selected techniques. Public Opin Q. 1988;52:467–91.View ArticleGoogle Scholar
- Edwards P, Roberts I, Clarke M, DiGuiseppi C, Pratap S, Wentz R. Increasing response rates to postal questionnaires: systematic review. Br Med J. 2002;324:1183–5.View ArticleGoogle Scholar
- Nakash RA, Hutton JL, Jørstad-Stein EC, Gates S, Lamb SE. Maximising response to postal questionnaires—a systematic review of randomised trials in health research. BMC Med Res Methodol. 2006;6:5.View ArticlePubMedPubMed CentralGoogle Scholar
- Glidewell L, Thomas R, MacLennan G, Bonetti D, Johnston M, Eccles MP, et al. Do incentives, reminders or reduced burden improve healthcare professional response rates in postal questionnaires? Two randomised controlled trials. BMC Health Serv Res. 2012;12:250.View ArticlePubMedPubMed CentralGoogle Scholar
- Baxter J, Vehik K, Bennett Johnson S, Lernmark B, Roth R, Simellg T, the TEDDY Study Group. Differences in recruitment and early retention among ethnic minority participants in a large pediatric cohort: the TEDDY Study. Contemp Clin Trials. 2012;33:633–40.View ArticlePubMedPubMed CentralGoogle Scholar
- Steffen AD, Kolonel LN, Nomura AM, Nagamine FS, Monroe KR, Wilkensi LR. The effect of multiple mailings on recruitment: the Multiethnic Cohort. Cancer Epid Biomar Prev. 2008;17:447–54.View ArticleGoogle Scholar
- Khosropour CM, Johnson BA, Ricca AV, Sullivan PS. Enhancing retention of an Internet-based cohort study of men who have sex with men (MSM) via text messaging: randomized controlled trial. J Med Internet Res. 2013;15:e194.View ArticlePubMedPubMed CentralGoogle Scholar
- Peterson JC, Pirraglia PA, Wells MT, Charlson ME. Attrition in longitudinal randomized controlled trials: home visits make a difference. BMC Med Res Methodol. 2012;12:178.View ArticlePubMedPubMed CentralGoogle Scholar
- Wakabayashi C, Hayashi K, Nagai K, Sakamoto N, Iwasaki Y. Effect of stamped reply envelopes and timing of newsletter delivery on response rates of mail survey: a randomised controlled trial in a prospective cohort study. BMJ Open. 2012;2(5):e001181.View ArticlePubMedPubMed CentralGoogle Scholar
- Gates S, Williams MA, Withers E, Williamson E, Mt-Isa S, Lamb SE. Does a monetary incentive improve the response to a postal questionnaire in a randomised controlled trial? The MINT incentive study. Trials. 2009;10:44.View ArticlePubMedPubMed CentralGoogle Scholar
- Booker CL, Seeromanie H, Benzeval M. A systematic review of the effect of retention methods in population-based cohort studies. BMC Public Health. 2011;11:249.View ArticlePubMedPubMed CentralGoogle Scholar
- 45 and Up Study Collaborators. Cohort Profile: the 45 and Up Study. Int J Epidemiol. 2008;37:941–7.View ArticlePubMed CentralGoogle Scholar
- Sax Institute: 45 and Up Study. https://www.saxinstitute.org.au/our-work/45-up-study/. Accessed 30 August 2015.
- Mealing NM, Banks E, Jorm LR, Steel DG, Clements MS, Rogers KD. Investigation of relative risk estimates from studies of the same population with contrasting response rates and designs. BMC Med Res Methodol. 2010;10:1.View ArticleGoogle Scholar
- Rothman KJ, Gallacher J, Hatch EE. Why representativeness should be avoided. Int J Epidemiol. 2013;42:1012–4.View ArticlePubMedPubMed CentralGoogle Scholar
- Ebrahim S, Davey Smith G. Commentary: Should we always deliberately be non-representative? Int J Epidemiol. 2013;42:1022–6.View ArticlePubMedGoogle Scholar
- SAS Institute Inc. SAS/STAT® 9.2 User’s Guide. Cary: SAS Institute Inc.; 2008.
- Thompson ML, Myers J, Kriebel D. Prevalence odds ratio or prevalence ratio in the analysis of cross sectional data: What is to be done? Occup Environ Med. 1998;55(4):272–7.View ArticlePubMedPubMed CentralGoogle Scholar
- StataCorp. Stata statistical software, release 13.0. College Station: Stata Corporation; 2013.Google Scholar
- Nakash RA, Hutton JL, Lamb SE, Gates S, Fisher J. Response and non-response to postal questionnaire follow-up in a clinical trial—a qualitative study of the patient’s perspective. J Eval Clin Pract. 2008;14:226–35.View ArticlePubMedGoogle Scholar
- Singh-Manoux A, Kivimaki M, Glymour MM, Elbaz A, Berr C, Ebmeier KP, et al. Timing of onset of cognitive decline: results from Whitehall II prospective cohort study. BMJ. 2012;344:d7622.View ArticlePubMedPubMed CentralGoogle Scholar