Watson-Jones D, Weiss HA, Rusizoka M, Changalucha J, Baisley K, Mugeye K, Tanton C, Ross D, Everett D, Clayton T, Balira R, Knight L, Hambleton I, LeGoff J, Belec L, Hayes R: Effect of herpes simplex suppression on incidence of HIV among women in Tanzania. N Engl J Med. 2008, 358: 1560-1571. 10.1056/NEJMoa0800260
Article
PubMed Central
CAS
PubMed
Google Scholar
Celum C, Wald A, Hughes J, Sanchez J, Reid S, Delany-Moretlwe S, Cowan F, Casapia M, Oritz A, Fuchs J, Buchbinder S, Koblin B, Zwerski S, Rose S, Wang J, Corey L: Twice Daily Acyclovir Does Not Reduce the Risk of HIV-1 Acquisition among HSV-2 Seropositive Women and Men who have sex with Men (MSM). Lancet. 2008, 371: 2109-2191. 10.1016/S0140-6736(08)60920-4
Article
PubMed Central
CAS
PubMed
Google Scholar
Padian NS, Straten van der A, Ramjee G, Chipato T, de Bruyn G, Blanchard K, Shiboski S, Montgomery ET, Fancher H, Cheng H, Rosenblum M, Laan van der M, Jewell N, McIntyre J: Diaphragm and lubricant gel for prevention of HIV acquisition in southern African women: a randomised controlled trial. Lancet. 2007, 370: 251-261. 10.1016/S0140-6736(07)60950-7
Article
PubMed Central
PubMed
Google Scholar
Robertson M, Mehrotra D, Fitzgerald D, Duerr A, Casimiro J, McElrath J, Lawrence D, Buchbinder S: Efficacy Results from the STEP Study (Merck V520 Protocol 023/HVTN 502): A Phase II Test-of-Concept Trial of the MRKAd5 HIV-1 Gag/Pol/Nef Trivalent Vaccine. CROI; February 3–6, 2008; Boston. 2008
Google Scholar
Gray RH, Kigozi G, Serwadda D, Makumbi F, Watya S, Nalugoda F, Kiwanuka N, Moulton LH, Chaudhary MA, Chen MZ, Sewankambo N, Wabwire-Mangen F, Bacon MC, Williams CF, Opendi P, Reynolds SJ, Laeyendecker O, Quinn TC, Wawer MJ: Male circumcision for HIV prevention in men in Rakai, Uganda: a randomised trial. Lancet. 2007, 369: 657-666. 10.1016/S0140-6736(07)60313-4
Article
PubMed
Google Scholar
Bailey RC, Moses S, Parker CB, Agot K, Maclean I, Krieger JN, Williams CF, Campbell RT, Ndinya-Achola JO: Male circumcision for HIV prevention in young men in Kisumu, Kenya: a randomised controlled trial. Lancet. 2007, 369: 643-656. 10.1016/S0140-6736(07)60312-2
Article
PubMed
Google Scholar
Auvert B, Taljaard D, Lagarde E, Sobngwi-Tambekou J, Sitta R, Puren A: Randomized, controlled intervention trial of male circumcision for reduction of HIV infection risk: the ANRS 1265 Trial. PLoS Med. 2005, 2: e298. 10.1371/journal.pmed.0020298
Article
PubMed Central
PubMed
Google Scholar
Grosskurth H, Mosha F, Todd J, Mwijarubi E, Klokke A, Senkoro K, Mayaud P, Changalucha J, Nicoll A, ka-Gina G, Newell J, Mugeye K, Mabey D, Hayes RJ: Impact of improved treatment of sexually transmitted diseases on HIV infection in rural Tanzania: randomised controlled trial. Lancet. 1995, 346: 530-536. 10.1016/S0140-6736(95)91380-7
Article
CAS
PubMed
Google Scholar
Hayes RJ, Schulz KF, Plummer FA: The cofactor effect of genital ulcers on the per-exposure risk of HIV transmission in sub-Saharan Africa. J Trop Med Hyg. 1995, 98: 1-8.
CAS
PubMed
Google Scholar
Rottingen JA, Garnett GP: The epidemiological and control implications of HIV transmission probabilities within partnerships. Sex Transm Dis. 2002, 29: 818-827. 10.1097/00007435-200212000-00014
Article
PubMed
Google Scholar
Wawer MJ, Gray RH, Sewankambo NK, Serwadda D, Li X, Laeyendecker O, Kiwanuka N, Kigozi G, Kiddugavu M, Lutalo T, Nalugoda F, Wabwire-Mangen F, Meehan MP, Quinn TC: Rates of HIV-1 transmission per coital act, by stage of HIV-1 infection, in Rakai, Uganda. J Infect Dis. 2005, 191: 1403-1409. 10.1086/429411
Article
PubMed
Google Scholar
Vittinghoff E, Douglas J, Judson F, McKirnan D, MacQueen K, Buchbinder SP: Per-contact risk of human immunodeficiency virus transmission between male sexual partners. Am J Epidemiol. 1999, 150: 306-311.
Article
CAS
PubMed
Google Scholar
Weiss HA, Quigley MA, Hayes RJ: Male circumcision and risk of HIV infection in sub-Saharan Africa: a systematic review and meta-analysis. Aids. 2000, 14: 2361-2370. 10.1097/00002030-200010200-00018
Article
CAS
PubMed
Google Scholar
Kaul R, Kimani J, Nagelkerke NJ, Fonck K, Ngugi EN, Keli F, MacDonald KS, Maclean IW, Bwayo JJ, Temmerman M, Ronald AR, Moses S: Monthly antibiotic chemoprophylaxis and incidence of sexually transmitted infections and HIV-1 infection in Kenyan sex workers: a randomized controlled trial. Jama. 2004, 291: 2555-2562. 10.1001/jama.291.21.2555
Article
CAS
PubMed
Google Scholar
Kamali A, Quigley M, Nakiyingi J, Kinsman J, Kengeya-Kayondo J, Gopal R, Ojwiya A, Hughes P, Carpenter LM, Whitworth J: Syndromic management of sexually-transmitted infections and behaviour change interventions on transmission of HIV-1 in rural Uganda: a community randomised trial. Lancet. 2003, 361: 645-652. 10.1016/S0140-6736(03)12598-6
Article
CAS
PubMed
Google Scholar
Wawer MJ, Sewankambo NK, Serwadda D, Quinn TC, Paxton LA, Kiwanuka N, Wabwire-Mangen F, Li C, Lutalo T, Nalugoda F, Gaydos CA, Moulton LH, Meehan MO, Ahmed S, Gray RH: Control of sexually transmitted diseases for AIDS prevention in Uganda: a randomised community trial. Rakai Project Study Group. Lancet. 1999, 353: 525-535. 10.1016/S0140-6736(98)06439-3
Article
CAS
PubMed
Google Scholar
White RG, Orroth KK, Korenromp EL, Bakker R, Wambura M, Sewankambo NK, Gray RH, Kamali A, Whitworth JA, Grosskurth H, Habbema JD, Hayes RJ: Can population differences explain the contrasting results of the Mwanza, Rakai, and Masaka HIV/sexually transmitted disease intervention trials?: A modeling study. J Acquir Immune Defic Syndr. 2004, 37: 1500-1513. 10.1097/01.qai.0000127062.94627.31
Article
PubMed
Google Scholar
Orroth KK, White RG, Korenromp EL, Bakker R, Changalucha J, Habbema JD, Hayes RJ: Empirical observations underestimate the proportion of human immunodeficiency virus infections attributable to sexually transmitted diseases in the Mwanza and Rakai sexually transmitted disease treatment trials: Simulation results. Sex Transm Dis. 2006, 33: 536-544. 10.1097/01.olq.0000204667.11192.71
Article
PubMed
Google Scholar
Korenromp EL, White RG, Orroth KK, Bakker R, Kamali A, Serwadda D, Gray RH, Grosskurth H, Habbema JD, Hayes RJ: Determinants of the impact of sexually transmitted infection treatment on prevention of HIV infection: a synthesis of evidence from the Mwanza, Rakai, and Masaka intervention trials. J Infect Dis. 2005, 191 (Suppl 1): S168-178. 10.1086/425274
Article
PubMed
Google Scholar
Grosskurth H, Gray R, Hayes R, Mabey D, Wawer M: Control of sexually transmitted diseases for HIV-1 prevention: understanding the implications of the Mwanza and Rakai trials. Lancet. 2000, 355: 1981-1987. 10.1016/S0140-6736(00)02336-9
Article
CAS
PubMed
Google Scholar
DHS: Zimbabwe 2005–2006 Demographic and Health Surveys.
DHS: South Africa 1998 Demographic and Health Surveys.
Mills EJ, Nachega JB, Buchan I, Orbinski J, Attaran A, Singh S, Rachlis B, Wu P, Cooper C, Thabane L, Wilson K, Guyatt GH, Bangsberg DR: Adherence to antiretroviral therapy in sub-Saharan Africa and North America: a meta-analysis. JAMA. 2006, 296: 679-690. 10.1001/jama.296.6.679
Article
CAS
PubMed
Google Scholar
Koblin B, Chesney M, Coates T: Effects of a behavioural intervention to reduce acquisition of HIV infection among men who have sex with men: the EXPLORE randomised controlled study. Lancet. 2004, 364: 41-50. 10.1016/S0140-6736(04)16588-4
Article
CAS
PubMed
Google Scholar
Corbett EL, Makamure B, Cheung YB, Dauya E, Matambo R, Bandason T, Munyati SS, Mason PR, Butterworth AE, Hayes RJ: HIV incidence during a cluster-randomized trial of two strategies providing voluntary counselling and testing at the workplace, Zimbabwe. Aids. 2007, 21: 483-489. 10.1097/QAD.0b013e3280115402
Article
PubMed
Google Scholar
Pronyk PM, Hargreaves JR, Kim JC, Morison LA, Phetla G, Watts C, Busza J, Porter JD: Effect of a structural intervention for the prevention of intimate-partner violence and HIV in rural South Africa: a cluster randomised trial. Lancet. 2006, 368: 1973-1983. 10.1016/S0140-6736(06)69744-4
Article
PubMed
Google Scholar
Ross DA, Changalucha J, Obasi AI, Todd J, Plummer ML, Cleophas-Mazige B, Anemona A, Everett D, Weiss HA, Mabey DC, Grosskurth H, Hayes RJ: Biological and behavioural impact of an adolescent sexual health intervention in Tanzania: a community-randomized trial. AIDS. 2007, 21: 1943-1955. 10.1097/QAD.0b013e3282ed3cf5
Article
PubMed
Google Scholar
NIMH Collaborative HIV/STD Prevention Trial Group: Methodological overview of a five-country community-level HIV/sexually transmitted disease prevention trial. AIDS. 2007, 21 (Suppl 2): S3-18.
Article
Google Scholar
NIMH Project Accept/HPTN 043 http://www.cbvct.med.ucla.edu/overview.html#contact
The Regai Dzive Shiri Programme: 2002–2007 http://spw.org/downloads/SPW_RDS_summary.pdf
Wawer MJ, Kigozi G, Serwadda D, Watya S, Makumbi F, Nalugoda F, Watya S, Buwembo D, Ssempija V, Moulton L, Gray R: Trial of male circumcision in HIV+ men: effects in men and women. 15th Conference on Retroviruses and Opportunistic Infections. Boston. 2008.
Google Scholar
Feldblum PJ, Adeiga A, Bakare R, Wevill S, Lendvay A, Obadaki F, Olayemi MO, Wang L, Nanda K, Rountree W: SAVVY vaginal gel (C31G) for prevention of HIV infection: a randomized controlled trial in Nigeria. PLoS ONE. 2008, 3: e1474. 10.1371/journal.pone.0001474
Article
PubMed Central
PubMed
Google Scholar
Halpern V, Wang L, Obunge O, Ogunsola F, Mehta N, Onyejepu N, Oduyebo O, Taylor D, Otusanya S, Umo-Otong J, McNeil L, Bragg V, Cates W: Effectiveness of cellulose sulfate gel for prevention of HIV: results of the phase III trial in Nigeria. 4th IAS Conference on HIV Pathogenesis, Treatment and Prevention. 2007.
Google Scholar
Kreiss J, Ngugi E, Holmes K, Ndinya-Achola J, Waiyaki P, Roberts PL, Ruminjo I, Sajabi R, Kimata J, Fleming TR: Efficacy of nonoxynol 9 contraceptive sponge use in preventing heterosexual acquisition of HIV in Nairobi prostitutes. JAMA. 1992, 268: 477-482. 10.1001/jama.268.4.477
Article
CAS
PubMed
Google Scholar
Peterson L, Nanda K, Opoku BK, Ampofo WK, Owusu-Amoako M, Boakye AY, Rountree W, Troxler A, Dominik R, Roddy R, Dorflinger L: SAVVY (C31G) gel for prevention of HIV infection in women: a Phase 3, double-blind, randomized, placebo-controlled trial in Ghana. PLoS ONE. 2007, 2: e1312. 10.1371/journal.pone.0001312
Article
PubMed Central
PubMed
Google Scholar
Population Council: Trial Shows Anti-HIV Microbicide Is Safe, but Does Not Prove It Effective. Press Release. New York 2008.
Google Scholar
Richardson BA, Lavreys L, Martin HL Jr, Stevens CE, Ngugi E, Mandaliya K, Bwayo J, Ndinya-Achola J, Kreiss JK: Evaluation of a low-dose nonoxynol-9 gel for the prevention of sexually transmitted diseases: a randomized clinical trial. Sex Transm Dis. 2001, 28: 394-400. 10.1097/00007435-200107000-00006
Article
CAS
PubMed
Google Scholar
Roddy RE, Zekeng L, Ryan KA, Tamoufe U, Weir SS, Wong EL: A controlled trial of nonoxynol 9 film to reduce male-to-female transmission of sexually transmitted diseases. N Engl J Med. 1998, 339: 504-510. 10.1056/NEJM199808203390803
Article
CAS
PubMed
Google Scholar
Van Damme L, Govinden R, Mirembe F, Guedou F, Solomon S, Becker ML, Pradeep B, Alary M, Nakabiito C, Ramjee G, Murphy S, Deese J, Crucitti T, Taylor D: Phase III trial of 6% cellulose sulfate (CS) gel for the prevention of HIV transmission. 4th IAS Conference on HIV Pathogenesis, Treatment and Prevention. Sydney, Australia 2007.
Google Scholar
Van Damme L, Ramjee G, Alary M, Vuylsteke B, Chandeying V, Rees H, Sirivongrangson P, Mukenge-Tshibaka L, Ettiegne-Traore V, Uaheowitchai C, Karim SS, Masse B, Perriens J, Laga M: Effectiveness of COL- a nonoxynol-9 vaginal gel, on HIV-1 transmission in female sex workers: a randomised controlled trial. Lancet. 1492, 360: 971-977. 10.1016/S0140-6736(02)11079-8. 10.1016/S0140-6736(02)11079-8
Article
Google Scholar
Phase II/IIb Safety and Effectiveness Study of the Vaginal Microbicides BufferGel and 0.5% PRO2000/5 Gel (P) for the Prevention of HIV Infection in Women http://clinicaltrials.gov/ct/show/NCT00074425?order=1
Phase IIb Trial to Assess the Safety and Effectiveness of the Vaginal Microbicide 1% Tenofovir Gel for the Prevention of HIV Infection in Women in South Africa http://clinicaltrials.gov/show/NCT00441298
Trial to Evaluate PRO 2000/5 Gels for the Prevention of Vaginally Acquired HIV Infection http://clinicaltrials.gov/ct/show/NCT00262106?order=2
Bangkok Tenofovir Study http://clinicaltrials.gov/ct2/show/NCT00119106?term=Thailand+CDC&rank=2
Botswana TDF/FTC Oral HIV Prophylaxis Trial http://clinicaltrials.gov/ct2/show/NCT00448669?term=botswana&rank=1
Anti-HIV Medications for the Prevention of HIV Infection in Latin American Men Who Have Sex With Men http://clinicaltrials.gov/ct/show/NCT00350324;jsessionid=C6AE509A400FD7C0031FC56FD42AE515?order=39
Pre-Exposure Prophylaxis to Prevent HIV-1 Acquisition Within HIV-1 Discordant Couples (PartnersPrEP) http://clinicaltrials.gov/ct2/show/NCT00557245?intr=%22Placebo%22&rank=30
A Randomized Trial to Evaluate the Effectiveness of Antiretroviral Therapy Plus HIV Primary Care versus HIV Primary Care Alone to Prevent the Sexual Transmission of HIV-1 in Serodiscordant Couples http://www.hptn.org/research_studies/hptn052.asp
Herpes Simplex Virus Type 2 (HSV-2) Suppression to Prevent HIV Transmission http://clinicaltrials.gov/show/NCT00194519?order=32
Gregson S, Adamson S, Papaya S, Mundondo J, Nyamukapa CA, Mason PR, Garnett GP, Chandiwana SK, Foster G, Anderson RM: Impact and process evaluation of integrated community and clinic-based HIV-1 control: a cluster-randomised trial in eastern Zimbabwe. PLoS Med. 2007, 4: e102. 10.1371/journal.pmed.0040102
Article
PubMed Central
PubMed
Google Scholar
Flynn NM, Forthal DN, Harro CD, Judson FN, Mayer KH, Para MF: Placebo-controlled phase 3 trial of a recombinant glycoprotein 120 vaccine to prevent HIV-1 infection. J Infect Dis. 2005, 191: 654-665. 10.1086/428404
Article
PubMed
Google Scholar
Safety and Efficacy of a Three-Dose Regimen of an Adenoviral HIV Vaccine (MRKAd5 HIV-1 Gag/Pol/Nef) in HIV Uninfected South African Adults http://clinicaltrials.gov/ct/show/NCT00413725;jsessionid=A6758E80AEA5A1111E76F301C01DE11E?order=2
Pitisuttithum P, Gilbert P, Gurwith M, Heyward W, Martin M, van Griensven F, Hu D, Tappero JW, Choopanya K: Randomized, double-blind, placebo-controlled efficacy trial of a bivalent recombinant glycoprotein 120 HIV-1 vaccine among injection drug users in Bangkok, Thailand. J Infect Dis. 2006, 194: 1661-1671. 10.1086/508748
Article
CAS
PubMed
Google Scholar
Rerks-Ngarm S, Brown AE, Khamboonruang C, Thongcharoen P, Kunasol P: HIV/AIDS preventive vaccine 'prime-boost' phase III trial: foundations and initial lessons learned from Thailand. Aids. 2006, 20: 1471-1479. 10.1097/01.aids.0000237362.26370.f8
Article
PubMed
Google Scholar