Table 1 Statistical findings of data simulation using log-linear models (scenario outlined in Figure 5)
From: Can we apply the Mendelian randomization methodology without considering epigenetic effects?
|
Gene → asthma (βITT) |
Gene → gene expression of CC (βXG*) |
Gene expression of CC → asthma (βIV ') | ||||
|---|---|---|---|---|---|---|
| β | SE | Â | SE | β | SE | |
| Effect of genetic polymorphism on asthma | ||||||
| CG/GG (reference) | 1 | |||||
| CC | 0.458 | 0.141 | ||||
| Effect of genetic polymorphisms on gene expression: | ||||||
| CG/GG (reference) | 1 | |||||
| CC | 0.367 | 0.055 | ||||
| Effect of genetic polymorphism, maternal and offspring smoking, and gene-"maternal smoking in adolescence" interaction on gene expression: | ||||||
| CG/GG (reference) | 1 | |||||
| CC | 0.215 | 0.086 | ||||
| Maternal smoking | 0.983 | 0.086 | ||||
| "Maternal smoking in adolescence" × CC-genotype | 0.269 | 0.111 | ||||
| Offspring smoking | -0.005 | 0.056 | ||||
| Effect of expression of genetic olymorphism on asthma: | ||||||
| Gene expression of CC | 1.951 | 0.135 | ||||
| Effect of genetic polymorphism, maternal and offspring smoking on asthma | ||||||
| Gene expression of CC | 1.792 | 0.144 | ||||
| "Maternal smoking in adolescence" | 0.435 | 0.145 | ||||
| Offspring smoking | 0.166 | 0.140 | ||||