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Table 1 Statistical findings of data simulation using log-linear models (scenario outlined in Figure 5)

From: Can we apply the Mendelian randomization methodology without considering epigenetic effects?

  Gene → asthma
(βITT)
Gene → gene expression of CC
(βXG*)
Gene expression of CC → asthma
(βIV ')
  β SE Â SE β SE
Effect of genetic polymorphism on asthma       
CG/GG (reference) 1      
CC 0.458 0.141     
Effect of genetic polymorphisms on gene expression:       
CG/GG (reference)    1    
CC    0.367 0.055   
Effect of genetic polymorphism, maternal and offspring smoking, and gene-"maternal smoking in adolescence" interaction on gene expression:       
CG/GG (reference)    1    
CC    0.215 0.086   
Maternal smoking    0.983 0.086   
"Maternal smoking in adolescence" × CC-genotype    0.269 0.111   
Offspring smoking    -0.005 0.056   
Effect of expression of genetic olymorphism on asthma:       
Gene expression of CC      1.951 0.135
Effect of genetic polymorphism, maternal and offspring smoking on asthma       
Gene expression of CC      1.792 0.144
"Maternal smoking in adolescence"      0.435 0.145
Offspring smoking      0.166 0.140
  1. # SE = standard error